Patent alert for targeted protein degradation

Patent alert for targeted protein degradation

Journal article

1 volume.

This article develops a search strategy for a weekly alert in the field of targeted protein degradation (TPD). The task is challenging due to the rapid evolution of therapeutic approaches, the complexity of patent publication feeds, nuances in patent database indexing, language translation issues, and the tendency of inventors and attorneys to use unique terminology. TPD is an emerging, multidisciplinary technology that aims to redirect molecules to hijack natural protein degradation pathways, targeting previously “undruggable” proteins. Unlike traditional “occupancy-driven” drugs, TPD drugs use “event-driven” pharmacology, initiating specific biological events such as protein degradation or modulation of protein-protein interactions (PPIs). This article provides an overview of TPD, presents a patent search strategy for identifying small molecules targeting the ubiquitin-proteasome system (UPS), and highlights the need for effective innovation tracking in this field.

Crossref

World Patent Information ; 84, March, 2026

World Patent Information

Oxford [England] : Elsevier Ltd., 2026.

eng

https://www.sciencedirect.com/science/article/abs/pii/S0172219023000108

External Online Journals > World Patent Information