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\def\WIPO{World Intellectual Property Organisation}
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Cite
Title
Patent alert for targeted protein degradation
Author
Item Type
Journal article
Description
1 volume.
Summary
This article develops a search strategy for a weekly alert in the field of targeted protein degradation (TPD). The task is challenging due to the rapid evolution of therapeutic approaches, the complexity of patent publication feeds, nuances in patent database indexing, language translation issues, and the tendency of inventors and attorneys to use unique terminology. TPD is an emerging, multidisciplinary technology that aims to redirect molecules to hijack natural protein degradation pathways, targeting previously “undruggable” proteins. Unlike traditional “occupancy-driven” drugs, TPD drugs use “event-driven” pharmacology, initiating specific biological events such as protein degradation or modulation of protein-protein interactions (PPIs). This article provides an overview of TPD, presents a patent search strategy for identifying small molecules targeting the ubiquitin-proteasome system (UPS), and highlights the need for effective innovation tracking in this field.
Source of Description
Crossref
Series
World Patent Information ; 84, March, 2026
In
World Patent Information
Linked Resources
Published
Oxford [England] : Elsevier Ltd., 2026.
Language
English
Copyright Information
https://www.sciencedirect.com/science/article/abs/pii/S0172219023000108
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