1. Introduction; 2. WTO jurisprudence and experience in TRIPS cross-retaliation; 3. The economic rationale for cross-retaliation inder the TRIPS agreement; 4. Multilateral, Regional and Bilateral commitments; 5. Broad level of suspension issues under the TRIPS agreement; 6. Subject matter specific level of suspension issues; 7. Practical considerations for developing countries regarding suspension of concessions under the TRIPS agreement; 8. Conclusion.